Protein Details: Potassium voltage-gated channel subfamily KQT member 4
Protein ID
ICDB_Pro_0634
Protein Name
Potassium voltage-gated channel subfamily KQT member 4
Gene Name
KCNQ4
Organism
Homo sapiens (Human)
Length
695 amino acids
AlphaFoldDB
AF-P56696-F1-model_v4.pdb
Function
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin;XE991 and bepridil;whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors
Sequence
Ligand Binding
Binding Site
ML213: KCNQ2/Q4 channel opener
Disease
Deafness;Autosomal Dominant 2A and Dfna2 Nonsyndromic Hearing Loss
Location
Expressed in the outer; but not the inner; sensory hair cells of the cochlea. Slightly expressed in heart; brain and skeletal muscle.
DOI ID
10.1016/s0092-8674(00)80556-5; 10.1038/nature04727; 10.1111/j.1469-7793.2000.t01-2-00349.x; 10.1152/ajpcell.2001.280.4.c859; 10.1371/journal.pone.0057282; 10.1073/pnas.1714760115; 10.1016/j.neuron.2007.02.010; 10.1093/hmg/8.7.1321; 10.1002/(sici)1098-1004(199912)14:6<493::aid-humu8>3.0.co;2-p; 10.1002/1096-8628(20000731)93:3<184::aid-ajmg4>3.0.co;2-5; 10.1001/archoto.2010.234
RefSeq
NP_004691.2 [P56696-1]; NP_751895.1 [P56696-2]